This journal article discusses anorexia, depression, and OCD. I wanted to put a link here because OCD may also present along with tics and/or Tourette Syndrome.
The mechanisms involved in the etiology and pathogenesis of mental and behavioral disorders related to CD are unclear. Hallert and Sedvall reported ...a 10% increase in the concentration of tryptophan in the cerebrospinal fluid (CSF) in adult CD patients after 1 year on a gluten-free diet.
Hernanz and Polanco found significantly decreased plasma concentrations of tryptophan, citrulline, tyrosine, valine, isoleucine, and leucine and significantly diminished ratios of tryptophan to large neutral amino acids in children with CD, regardless of dietary treatment. In untreated children, plasma tryptophan was 84% less (mean±SD=13±4 µmol/L) and in the treated group 62% less (31±3 µmol/L) than in children without CD (81±22 µmol/L), and the plasma tryptophan ratio was found to be significantly lower in the untreated group compared with the treated and control groups. Nine of 15 children with untreated CD showed signs of "behavioral disturbances" and were irritable or apathetic. In some of these patients, mood and behavioral problems improved after starting a gluten-free diet. However, to our knowledge, these findings have not been confirmed elsewhere.
To our knowledge, there are no studies based on structured psychiatric interviews that have examined mental disorders associated with CD in children and adolescents. We describe two adolescent patients who suffered from severe mental and behavioral disorders before receiving a CD diagnosis. In both cases, psychiatric status considerably improved soon after the commencement of a gluten-free diet.
I found the study and the outcome quite interesting.
http://psy.psychiatryonline.org
